{"id":27591,"date":"2025-07-21T20:23:10","date_gmt":"2025-07-21T17:23:10","guid":{"rendered":"https:\/\/www.neolife.com.tr\/?page_id=27591"},"modified":"2025-09-17T10:12:42","modified_gmt":"2025-09-17T07:12:42","slug":"aktinijum-225-psma","status":"publish","type":"page","link":"https:\/\/www.neolife.com.tr\/sr\/aktinijum-225-psma\/","title":{"rendered":"Aktinijum-225 PSMA"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"27591\" class=\"elementor elementor-27591\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-106a2ab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"106a2ab\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-342e508\" data-id=\"342e508\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a358d8a elementor-widget elementor-widget-text-editor\" data-id=\"a358d8a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 data-start=\"69\" data-end=\"87\"><strong data-start=\"73\" data-end=\"87\">Indikacija<\/strong><\/h4><p data-start=\"89\" data-end=\"287\">Terapija Aktinijumom-225 PSMA koristi se kod pacijenata sa metastatskim karcinomom prostate rezistentnim na kastraciju, kada standardne opcije le\u010denja nisu bile efikasne ili se nisu mogle primeniti.<\/p><h4><strong data-start=\"298\" data-end=\"337\">\u0160ta je terapija Aktinijum-225 PSMA?<\/strong><\/h4><p data-start=\"339\" data-end=\"640\">Aktinijum-225 PSMA terapija, nova zvezda u teranosti\u010dkoj medicini, nudi jedinstven pristup detekciji tumora i metastaza, a zatim i njihovom ciljanom le\u010denju specifi\u010dnim lekom. Ova metoda predstavlja primer prelaska na savremenu medicinu zasnovanu na individualnom zdravstvenom stanju svakog pacijenta.<\/p><p data-start=\"642\" data-end=\"925\">Kod karcinoma prostate, tumorska tkiva se mogu prikazati sa velikom osetljivo\u0161\u0107u i specifi\u010dno\u0161\u0107u pomo\u0107u Ga-68 PSMA PET\/CT, a zatim se sprovodi ciljano le\u010denje sa Ac-225 PSMA. Ovaj teranosti\u010dki pristup predstavlja inovativnu metodu koja se uspe\u0161no primenjuje uz ohrabruju\u0107e rezultate.<\/p><p data-start=\"927\" data-end=\"1351\">U kontekstu PSMA (prostata specifi\u010dni membranski antigen) ciljane radioligandne terapije, klini\u010dke studije faze 2 sa beta emituju\u0107im Lutecijum-177 (Lu-177) su uspe\u0161no zavr\u0161ene, dok su rezultati faze 3 pokazali ohrabruju\u0107e podatke. Me\u0111utim, terapija alfa \u010desticama ciljana sa Ac-225 PSMA do sada je ocenjivana kroz nekoliko pretklini\u010dkih eksperimenata, preliminarne dozimetrijske studije i retrospektivne posmatra\u010dke studije.<\/p><p data-start=\"1353\" data-end=\"1560\">Prva klini\u010dka iskustva pokazuju da Ac-225 PSMA posti\u017ee PSA odgovor &gt;50% kod 63\u201370% slu\u010dajeva, izra\u017een antitumorski efekat, trajanje odgovora od 10\u201315 meseci i kompletne remisije kod pribli\u017eno 10% pacijenata.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3744b6 elementor-widget elementor-widget-image\" data-id=\"b3744b6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"269\" height=\"269\" src=\"https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34.png\" class=\"attachment-large size-large wp-image-18019\" alt=\"\" srcset=\"https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34.png 269w, https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34-150x150.png 150w\" sizes=\"(max-width: 269px) 100vw, 269px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9624300 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9624300\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 data-start=\"1567\" data-end=\"1617\"><strong data-start=\"1571\" data-end=\"1617\">Lu-177 PSMA naspram Ac-225 PSMA: Pore\u0111enje<\/strong><\/h4><p data-start=\"1619\" data-end=\"1948\">Zbog nedostatka direktnih pore\u0111enja izme\u0111u Lu-177 PSMA i Ac-225 PSMA, jo\u0161 uvek nije mogu\u0107e sa sigurno\u0161\u0107u tvrditi superiornost jednog agensa nad drugim. Ipak, Ac-225 PSMA, kao terapija koja emituje alfa \u010destice, ima kra\u0107i domet u pore\u0111enju sa beta zra\u010denjem, \u0161to mu pru\u017ea potencijalne prednosti u odre\u0111enim klini\u010dkim indikacijama.<\/p><p data-start=\"1950\" data-end=\"2229\">Na primer, u slu\u010dajevima sa opse\u017enom infiltracijom ko\u0161tane sr\u017ei, Ac-225 PSMA mo\u017ee smanjiti izlaganje okolnih zdravih \u0107elija zra\u010denju. Jo\u0161 jedna prednost je u ablaciji mikrometastaza kod ranog stadijuma bolesti ili kod pacijenata koji su prethodno pozitivno odgovorili na le\u010denje.<\/p><p data-start=\"2231\" data-end=\"2572\">Pored toga, postoje preliminarni dokazi da Ac-225 PSMA obe\u0107ava kod pacijenata sa lo\u0161im odgovorom na Lu-177 PSMA ili kod onih sa nepovoljnim prognosti\u010dkim biomarkerima. Pretklini\u010dka istra\u017eivanja pokazala su da alfa zra\u010denje mo\u017ee izazvati ja\u010di abskopalni efekat u pore\u0111enju sa beta zra\u010denjem, \u0161to ukazuje na mogu\u0107u sinergiju sa imunoterapijom.<\/p><h4 data-start=\"2579\" data-end=\"2609\"><strong data-start=\"2583\" data-end=\"2609\">Ac-225: Karakteristike<\/strong><\/h4><p data-start=\"2611\" data-end=\"2869\">Ac-225 je impresivan radioaktivni element sa fizi\u010dkim poluvremenom raspada od oko 10 dana, \u0161to ga \u010dini superiornim u pogledu dostupnosti i ozna\u010davanja. Zahvaljuju\u0107i emisiji alfa \u010destica, Ac-225 PSMA ima znatno ve\u0107u biolo\u0161ku mo\u0107 u pore\u0111enju sa beta zra\u010denjem.<\/p><p data-start=\"2871\" data-end=\"3030\">Pojednostavljeno, <strong data-start=\"2889\" data-end=\"2910\">8 MBq Ac-225 PSMA<\/strong> mo\u017ee posti\u0107i isti biolo\u0161ki efekat <strong data-start=\"2945\" data-end=\"2972\">kao 7,4 GBq Lu-177 PSMA<\/strong>, omogu\u0107avaju\u0107i le\u010denje uz 1.000 puta manju dozu zra\u010denja.<\/p><h4 data-start=\"3037\" data-end=\"3072\"><strong data-start=\"3041\" data-end=\"3072\">Trenutne primene i pristupi<\/strong><\/h4><p data-start=\"3074\" data-end=\"3318\">Danas se primenjuju protokoli le\u010denja sa smanjenim dozama i \u201ekoktel\u201c re\u017eimi sa kombinacijom <strong data-start=\"3166\" data-end=\"3188\">Ac-225\/Lu-177 PSMA<\/strong> kako bi se smanjio rizik od razvoja kserostomije (sindroma suvih usta), \u010dime se pobolj\u0161ava podno\u0161ljivost terapije sa Ac-225 PSMA.<\/p><p data-start=\"3320\" data-end=\"3412\">Ovakav pristup omogu\u0107ava efikasno le\u010denje bez kompromitovanja antitumorskog efekta terapije.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Indikacija Terapija Aktinijumom-225 PSMA koristi se kod pacijenata sa metastatskim karcinomom prostate rezistentnim na kastraciju, kada standardne opcije le\u010denja nisu bile efikasne ili se nisu mogle primeniti. \u0160ta je terapija Aktinijum-225 PSMA? Aktinijum-225 PSMA terapija, nova zvezda u teranosti\u010dkoj medicini, nudi jedinstven pristup detekciji tumora i metastaza, a zatim i njihovom ciljanom le\u010denju specifi\u010dnim lekom. [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":22098,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-27591","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Aktinijum-225 PSMA - Neolife T\u0131p Merkezi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.neolife.com.tr\/sr\/aktinijum-225-psma\/\" \/>\n<meta name=\"twitter:label1\" content=\"\u041f\u0440\u043e\u0446\u0435\u045a\u0435\u043d\u043e \u0432\u0440\u0435\u043c\u0435 \u0447\u0438\u0442\u0430\u045a\u0430\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 \u043c\u0438\u043d\u0443\u0442\u0430\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.neolife.com.tr\/sr\/aktinijum-225-psma\/\",\"url\":\"https:\/\/www.neolife.com.tr\/sr\/aktinijum-225-psma\/\",\"name\":\"Aktinijum-225 PSMA - 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