{"id":27065,"date":"2025-07-15T17:37:03","date_gmt":"2025-07-15T14:37:03","guid":{"rendered":"https:\/\/www.neolife.com.tr\/?page_id=27065"},"modified":"2025-09-17T10:07:36","modified_gmt":"2025-09-17T07:07:36","slug":"actinium-225-psma","status":"publish","type":"page","link":"https:\/\/www.neolife.com.tr\/fr\/actinium-225-psma\/","title":{"rendered":"Actinium-225 PSMA"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"27065\" class=\"elementor elementor-27065\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-106a2ab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"106a2ab\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-342e508\" data-id=\"342e508\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a358d8a elementor-widget elementor-widget-text-editor\" data-id=\"a358d8a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><strong>Indication <\/strong><\/h4><p>La th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA est utilis\u00e9e chez les patients atteints d\u2019un cancer de la prostate m\u00e9tastatique r\u00e9sistant \u00e0 la castration, lorsque les options de traitement standard se sont r\u00e9v\u00e9l\u00e9es inefficaces ou ne peuvent pas \u00eatre appliqu\u00e9es.<\/p><h4><strong>Qu&rsquo;est-ce que la th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA ? <\/strong><\/h4><p>La th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA, une \u00e9toile montante de la m\u00e9decine th\u00e9ranostique, offre une approche unique permettant de d\u00e9tecter les tumeurs et les m\u00e9tastases, puis de les traiter \u00e0 l\u2019aide d\u2019un m\u00e9dicament sp\u00e9cifique. Cette m\u00e9thode illustre la transition vers des pratiques m\u00e9dicales modernes, centr\u00e9es sur l\u2019\u00e9tat de sant\u00e9 individuel de chaque patient. Dans le cancer de la prostate, les tissus tumoraux peuvent \u00eatre visualis\u00e9s avec une grande sensibilit\u00e9 et sp\u00e9cificit\u00e9 gr\u00e2ce au <strong>PET\/CT au Ga-68 PSMA,<\/strong> suivi d\u2019un traitement cibl\u00e9 par <strong>l\u2019Ac-225 PSMA<\/strong>. Cette approche th\u00e9ranostique repr\u00e9sente une m\u00e9thode novatrice, mise en \u0153uvre avec succ\u00e8s et des r\u00e9sultats prometteurs.<\/p><p>Dans le contexte de la radioth\u00e9rapie cibl\u00e9e par ligand du PSMA (antig\u00e8ne membranaire sp\u00e9cifique de la prostate), des essais cliniques de phase 2 utilisant <strong>le Lut\u00e9tium-177 (Lu-177)<\/strong>, un \u00e9metteur b\u00eata, ont \u00e9t\u00e9 men\u00e9s avec succ\u00e8s, et les essais de phase 3 ont montr\u00e9 des r\u00e9sultats encourageants. En revanche, la th\u00e9rapie par particules alpha cibl\u00e9e par <strong>l\u2019Ac-225 PSMA<\/strong> a jusqu\u2019\u00e0 pr\u00e9sent \u00e9t\u00e9 \u00e9valu\u00e9e par quelques exp\u00e9riences pr\u00e9cliniques, des \u00e9tudes dosim\u00e9triques pr\u00e9liminaires et des \u00e9tudes observationnelles r\u00e9trospectives. Les premi\u00e8res exp\u00e9riences cliniques indiquent que <strong>l\u2019Ac-225 PSMA<\/strong> permet une r\u00e9ponse en termes de <strong>PSA sup\u00e9rieure \u00e0 50 % dans 63 \u00e0 70 % des cas<\/strong>, avec un effet antitumoral prometteur, une dur\u00e9e de <strong>r\u00e9ponse de 10 \u00e0 15 mois<\/strong> et une r\u00e9mission compl\u00e8te chez environ <strong>10 % des patients<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3744b6 elementor-widget elementor-widget-image\" data-id=\"b3744b6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"269\" height=\"269\" src=\"https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34.png\" class=\"attachment-large size-large wp-image-18019\" alt=\"\" srcset=\"https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34.png 269w, https:\/\/www.neolife.com.tr\/wp-content\/uploads\/2023\/05\/Ellipse-34-150x150.png 150w\" sizes=\"(max-width: 269px) 100vw, 269px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9624300 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9624300\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><strong>Lu-177 PSMA vs. Ac-225 PSMA : Une comparaison <\/strong><\/h4><p>En raison du manque d\u2019\u00e9tudes comparatives entre le Lu-177 PSMA et l\u2019Ac-225 PSMA, il n\u2019est pas encore possible d\u2019affirmer de mani\u00e8re d\u00e9finitive la sup\u00e9riorit\u00e9 de l\u2019un par rapport \u00e0 l\u2019autre. Cependant, l\u2019Ac-225 PSMA, en tant que th\u00e9rapie \u00e9mettant des particules alpha, pr\u00e9sente une port\u00e9e plus courte que le rayonnement b\u00eata, ce qui lui conf\u00e8re des avantages potentiels dans certaines indications cliniques sp\u00e9cifiques. Par exemple, dans les cas <strong>d\u2019infiltration m\u00e9dullaire \u00e9tendue<\/strong>, l\u2019Ac-225 PSMA peut r\u00e9duire l\u2019exposition aux radiations des cellules saines environnantes. Un autre avantage est observ\u00e9 <strong>dans l\u2019ablation des microm\u00e9tastases<\/strong> chez les patients en phase pr\u00e9coce de la maladie ou ayant d\u00e9j\u00e0 r\u00e9pondu positivement \u00e0 un traitement ant\u00e9rieur.<\/p><p>De plus, des donn\u00e9es pr\u00e9liminaires sugg\u00e8rent que l\u2019Ac-225 PSMA repr\u00e9sente une option prometteuse pour les patients ayant une mauvaise r\u00e9ponse au Lu-177 PSMA ou pr\u00e9sentant des biomarqueurs pronostiques d\u00e9favorables. Des recherches pr\u00e9cliniques ont montr\u00e9 que le rayonnement alpha pourrait induire un effet abscopal plus puissant que le rayonnement b\u00eata, ce qui laisse entrevoir un potentiel synergique avec <strong>l\u2019immunoth\u00e9rapie<\/strong>.<\/p><p>L\u2019Ac-225 est un isotope radioactif remarquable avec <strong>une demi-vie physique d\u2019environ 10 jours<\/strong>, ce qui le rend sup\u00e9rieur en termes de disponibilit\u00e9 et de marquage. Gr\u00e2ce \u00e0 l\u2019\u00e9mission de particules alpha, l\u2019Ac-225 PSMA poss\u00e8de une puissance biologique bien plus \u00e9lev\u00e9e que le rayonnement b\u00eata. En termes simples, <strong>8 MBq d\u2019Ac-225 PSMA<\/strong> peuvent produire le m\u00eame effet biologique in vivo que <strong>7,4 GBq de Lu-177 PSMA,<\/strong> permettant ainsi un traitement avec des doses <strong>de rayonnement jusqu\u2019\u00e0 1 000 fois plus faibles.<\/strong><\/p><h4><strong>Applications actuelles et approches th\u00e9rapeutiques <\/strong><\/h4><p>Aujourd\u2019hui, des protocoles de traitement par d\u00e9sescalade ainsi que des r\u00e9gimes en tandem combinant Ac-225 et Lu-177 PSMA (appel\u00e9s \u00ab cocktails \u00bb) sont mis en \u0153uvre afin de r\u00e9duire le risque de x\u00e9rostomie (syndrome de la bouche s\u00e8che), am\u00e9liorant ainsi la tol\u00e9rance du traitement \u00e0 l\u2019Ac-225 PSMA. Cette approche permet d\u2019assurer une efficacit\u00e9 antitumorale tout en minimisant les effets secondaire<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Indication La th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA est utilis\u00e9e chez les patients atteints d\u2019un cancer de la prostate m\u00e9tastatique r\u00e9sistant \u00e0 la castration, lorsque les options de traitement standard se sont r\u00e9v\u00e9l\u00e9es inefficaces ou ne peuvent pas \u00eatre appliqu\u00e9es. Qu&rsquo;est-ce que la th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA ? La th\u00e9rapie \u00e0 l\u2019Actinium-225 PSMA, une \u00e9toile montante de [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":27067,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-27065","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Actinium-225 PSMA - Neolife T\u0131p Merkezi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.neolife.com.tr\/fr\/actinium-225-psma\/\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.neolife.com.tr\/fr\/actinium-225-psma\/\",\"url\":\"https:\/\/www.neolife.com.tr\/fr\/actinium-225-psma\/\",\"name\":\"Actinium-225 PSMA - 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